表皮生长因子在急性鼻窦炎黏膜修复过程中的作用及机制
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Effect and mechanism of epidermal growth factor in healing of nasal sinus mucosa in acute sinusitis
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    摘要:

    目的 观察表皮生长因子(Epidermal Growth Factor, EGF)对实验动物急性鼻窦炎鼻窦黏膜的愈合作用,以及其受体在鼻窦黏膜愈合过程中的表达变化。方法 在鼻窦炎动物模型建立后将兔麻醉,打开上颌窦前壁,在内镜下于上颌窦底做一黏膜缺损区。左侧上颌窦为对照组,每天用生理盐水处理窦腔;右侧上颌窦为实验组,每天应用含EGF的生理盐水进行窦腔处理。并取未经任何处理的兔子作为正常组。在实验开始后1、2、3、4周,各随机处死6只动物,比较观察两侧上颌窦黏膜创面愈合情况,以及表皮生长因子受体表达情况。结果 实验组EGF可有效促进鼻窦黏膜创面愈合,创面上皮化明显高于对照组,并且局部创缘表皮生长因子受体(EGFR)表达显著高于对照组。结论 EGF可通过刺激局部组织EGFR的表达从而促进鼻窦黏膜上皮化。

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    Objective To observe the effect of epidermal growth factor (EGF) on the healing of sinus mucosa impairment and the expression of EGFreceptor in sinus mucosa. Methods The model rabbits with rhinogenic sinusitis were anaesthetized, the anterior maxillary wall of each rabbit was opened surgically and mucosa defects were made at the inferior maxillary wall. For each rabbit, the right maxillary sinus was chosen as experimental side (experimental group) and treated with mixture of EGF and normal saline; the left sinus as control side (control group) and treated with normal saline only. At the timepoints of 1, 2, 3 and 4 weeks after surgery, every time 6 rabbits were sacrificed, then the healing status of maxillary sinus mucosa and the expression of EGFreceptor in both groups were observed and comparatively analysed. Results EGF could enhance the healing of mucosa defects. The epithelialization rate and expression of EGFreceptor in the experimental group were higher than those in the control group (P<0.01). Conclusion EGF can facilitate the epithelialization of sinus mucosa via stimulating the expression of EGFreceptor.

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.表皮生长因子在急性鼻窦炎黏膜修复过程中的作用及机制[J].中国耳鼻咽喉颅底外科杂志,2010,16(1):16-20

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  • 在线发布日期: 2010-02-28
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