信号转导抑制因子-3与磷酸化信号转导转录活化因子
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李晓明,Email:xml-968@sohu.com.

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Expression of SOCS3 and pSTAT3 in laryngeal squamous cellcarcinoma and the correlation with clinicopathological parameters
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    : 目的 研究细胞因子信号转导抑制因子3(suppressor of cytokine signaling3, SOCS3)在喉鳞状细胞癌(LSCC)组织中的表达,并进一步探讨SOCS3与磷酸化信号转导转录活化因子-3(phosphorylation signal transducer and activator of transcription 3, pSTAT3)的相关性及与喉癌临床病理因素的关系。方法 收集2005年2月~2009年2月在白求恩国际和平医院耳鼻咽喉头颈外科接受手术的LSCC石蜡标本40例,并选取11例正常喉黏膜组织作为对照。采用免疫组化染色法检测SOCS3、pSTAT3蛋白的表达情况。结果 ① LSCC组织中SCOS3蛋白表达明显低于正常喉黏膜组织,两者之间差异具有统计学意义(P=0.000);p-STAT3蛋白在正常喉黏膜组织中的表达小于喉癌组织(P=0.000);② LSCC组织中SOCS3与pSTAT3蛋白之间存在显著负相关(r=-0.459,P=0.003);③ SOCS-3表达与患者年龄(P=0.223)、性别(P=0.849)、肿瘤T分级(P=0.193)无相关性,而与肿瘤病理分期(P=0.000),淋巴结转移(P=0.000)有关。结论 ①在喉正常黏膜组织中SOCS3均呈阳性表达,而在LSCC组织中部分呈阳性表达;并与pSTAT3蛋白的表达情况呈负相关。提示SOCS3可能在喉癌生长的过程通过抑制JAK/STAT3信号转导通路的持续活化从而抑制喉癌细胞增长,促进细胞凋亡;② SOCS-3的表达与患者年龄、性别、肿瘤T分级无相关性,而与喉癌病理分期及颈部淋巴结转移有关。

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    Abstract: Objective To investigate the expression of suppressor of cytokine signaling3 (SOCS3) in laryngeal squamous cell carcinoma (LSCC), and to study the correlation between the expression of SOCS3 and signal transducer and activator of trans pSTAT3, and that between the expression of SOCS3 with clinicopathological factors of LSCC. Methods Immunohistochemical staining(SP method) was used for detecting the expression of SOCS3, pSTAT3 in 40 specimens of surgically resected LSCC and 11 of paracancerous normal laryngeal tissue. Results ① The expression of SOCS3 in LSCC was significantly lower than that in normal laryngeal tissue (P=0.000). The expression of pSTAT3 in normal laryngeal tissues was significantly lower than that in LSCC (P=0.000). ② Significant negative correlation was observed between the expression of SOCS3 and that of pSTAT3 (r=-0.459, P=0.003). ③ The expression of SOCS3 was significantly related with the pathologic grading and lymphatic metastasis, but not with the age, gender, and clinical stage of the patients. Conclusion The SOCS3 protein is omniexpressed in all normal laryngeal tissues, but less expressed in LSCC. The expression of SOCS3 is negatively correlated to that of pSTAT3, which suggests that SOCS3 plays an important role in inhibiting cell proliferation and promoting cell apoptosis in LSCC. The expression of SOCS3 protein is not related to patients’ age, gender, Tstage and tumor position, but related to cell differentiation level and lymphatic metastasis.

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李军 李晓明 路秀英 邸斌 陶振峰 宋琦.信号转导抑制因子-3与磷酸化信号转导转录活化因子[J].中国耳鼻咽喉颅底外科杂志,2012,18(3):165-169

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  • 在线发布日期: 2012-06-30
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