ObjectiveThe prognosis of hypopharyngeal carcinoma is poor due to high malignancy of the tumor, hidden anatomical location, atypical early symptoms, and easiness of invasion of the larynx and esophagus and other adjacent organs as well as high rates of cervical lymph node metastasis and distant metastasis. For earlystage patients, both larynx preserving surgery and radiotherapy can achieve good oncological and functional results, while for advancestage ones, traditionally, surgery followed by radiotherapy has been the treatment of choice and is functionally debilitating. The strategy of organ preservation with radiotherapy or chemoradiotherpy has been adopted for the purpose of cure of the disease and preservation of laryngeal function, but chemoradiotherapy has some kinds of acute and late toxicities. Therefore, multidiscipline treatments are absolutely recommended for this group of patients.