Raf-1激酶抑制蛋白在喉鳞癌中的表达及意义
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Expression of RKIP in laryngeal squamous cell carcinoma and its significance
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    摘要:

    目的 探讨Raf1激酶抑制蛋白( Raf 1 kinase inhibitor protein, RKIP )在喉鳞癌以及正常喉黏膜中的表达及意义。方法 采用免疫组化方法检测41例喉鳞癌及8例正常喉黏膜组织中RKIP、磷酸化的细胞外信号调节激酶(Phosphoextracellular signalregulated kinase, PERK)的表达情况。结果 喉鳞癌中RKIP表达比正常喉黏膜组织明显降低,差异有统计学意义(P=0.012)。RKIP在有淋巴结转移的喉癌中阳性率低于无转移的喉癌,差异有统计学意义(P=0.016)。有淋巴结转移的喉癌原发灶与其本身淋巴结转移灶间RKIP表达无显著差异。41例喉癌患者的原发灶标本中,RKIP与PERK的表达呈正相关性(P=0.003,r=0.456)。结论 RKIP低表达的喉癌更容易发生转移。丝裂原活化蛋白激酶(Mitogenactivated protein kinase,MAPK)通路受许多复杂的上游信号活化,喉癌中RKIP不能完全抑制该通路的活性。

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    Objective To investigate the expression and its clinical significance of raf1 kinase inhibitor protein (RKIP) in laryngeal squamous cell carcinoma and normal laryngeal squamous epithelium. Methods Immunohistochemistry was used for detecting the expression of RKIP and phosphoextracellular signalregulated kinase (PERK) in 41 specimens of laryngeal squamous cell carcinoma and 8 of normal laryngeal squamous epithelium. Results The expression of RKIP in specimens of laryngeal squamous cell carcinoma was lower than that in normal laryngeal squamous epithelium with significant difference (P<0.05). In specimens of laryngeal squamous cell carcinoma, RKIP positive staining rate in nodepositive tumors was lower than that in nodenegative ones, and the difference was significant (P<0.05). In specimens of laryngeal squamous cell carcinoma with lymphatic metastasis, the difference in RKIP expression between primary foci and metastatic lymph nodes was statistically insignificant. In specimens of primary foci, the expression of RKIP was positively correlated with that of PERK (P=0.003, r=0.456). Conclusion The primary laryngeal squamous cell carcinoma with reduced expression of RKIP tends toward metastasis. Mitogenactivated protein kinase( MAPK) pathway might be activated by multiple upstream signals, and RKIP can not suppress the activation of this pathway completely in laryngeal squamous cell carcinoma.

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张维 刘建 天津. Raf-1激酶抑制蛋白在喉鳞癌中的表达及意义[J].中国耳鼻咽喉颅底外科杂志,2010,16(1):7-10

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