OBJECTIVE:To assess the application, problems, and trend of statistical methods in two kinds of Chinese journals of clinical medicine published from 2005 to 2006. METHODS:A uniform questionnaire was adopted in the study and data was analyzed with SPSS13.0 software. RESULTS:643 original articles were included. Statistical methods were used in 86.5% of the articles with an accurate rate of 82.7%; the t test and contingency table analysis were most commonly used. Common mistakes were inappropriate use of t test, non interval estimation in linear correlation analysis, no formula in multiple regression analysis, ambiguity of statistical analysis methods, no exact P values and so on. CONCLUSION:The utilization and accuracy of statistical analysis have been significantly improved, the methods are more diversified, but inappropriate use and lack of statistical methods still exist.