OBJEVTIVE:To study the polymorphism of signal transduction and activator of transcription 6 (STAT6) gene and the relationship between STAT6 1570C/T and allergic rhinitis. METHODS:The study was conducted in two different groups: patients with allergic rhinitis (the case group, n=92) and healthy people (the control group, n=422). The STAT6 1570C/T polymorphism was genotyped with polymerasechain reactionrestriction fragment length polymorphism (PCRRFLP). The distribution frequencies of genotypes and allelic genes between the two groups were compared. RESULTS:The distribution frequencies of the three genotypes (TT, CT and CC) in the case group were 5.43%, 70.65% and 23.91% respectively, while those in the control group were 4.48%, 75% and 20.05% correspondingly. The differences of distribution frequencies of genotypes and allelic genes (T1570 and C1570) between the two groups were statistically insignificant (P>0.05). CONCLUSION:There are no significant differences in frequencies of the STAT6 gene 1570C/T polymorphism genotypes between patients with allergic rhinitis and normal controls, which hints that STAT6 (1570C/T) gene polymorphism may not be related to allergic rhinitis. 