Abstract: Objective To assess the clinical efficiency of Azelastine spray in the treatment of allergic rhinitis (AR). Methods Azelastine spray was applied to 235 patients with AR and the efficiency was separately assessed two weeks and two months after first application. Results The differences of total symptom scores before and after Azelastine treatment in patients with mild intermittent, middlesevere intermittent, mild perennial and middlesevere perennial AR were statistically significant (P<0.01). The effective rates in above groups were 95.9%, 80.7%, 95.1% and 77.9% respectively. Conclusion Azelastine spray can effectively relief the symptoms caused by Histamine and inflammatory cells and their mediators. Azelastine spray is effective and safe in the treatment of AR.