质子泵抑制剂在疑似咽喉反流性疾病中的应用
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唐先龙,Email:tangxianlong9525@126.com.

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Application of protonpump inhibitors to suspectedlaryngopharyngeal reflux diseases
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    摘要:

    摘要:目的 探讨质子泵抑制剂(protonpump inhibitors, PPI)试验性治疗在疑似咽喉反流性疾病(laryngopharyngeal reflux diease, LPRD )中的应用价值。方法 选取根据反流症状指数量表The reflux symptom index, RSI)和反流检查计分量表(The reflux finding score, RFS)均为阳性的130例我院门诊患者。随机分为质子泵抑制剂奥美拉唑治疗组和咽喉炎药物治疗组,分别治疗2周后再次追踪RSI和RFS评估。结果 2周治疗后PPI治疗组38例RSI评分下降,29例RFS评分下降,RFS评分无下降的仍有11例RSI下降,治疗前后RSI和RFS评分差异经检验具有统计学意义(P<0.01)。咽喉炎药物治疗组17例RSI评分下降,12例RFS评分下降,治疗前后RSI和RFS评分差异经检验无统计学意义(P>0.05)。结论 临床疑似咽喉反流性疾病可予短期质子泵抑制剂试验性治疗,其敏感性和特异性好,值得临床广泛应用。

    Abstract:

    Abstract: Objective To study the value of protonpump inhibitors (PPI) in the experimental treatment of suspected laryngopharyngeal reflux diseases (LPRD). Methods 65 patients with suspected LPRDs, according to the reflux symptom index (RSI) and reflux finding score (RFS), received shortterm Omeprazole (20 mg bid for two weeks) experimental treatment. The RSI and RFS were reevaluated two weeks after treatment. Results After treatment, RSI scores were descended in 38 cases (58.46%) and RFS scores descended in 29 cases (44.62%). Among the cases with steady RFS scores, 11 cases still got RSI scores descended. The differences of RSI and RFS scores were statistically significant before and after PPI experimental treatment. Conclusion Shortterm PPI experimental treatment, which can be administered to patients suffering from suspected LPRDs with good sensitivity and specificity, is worthy of extensive application in clinic.

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唐先龙 乔锋 庾江东 漆德良.质子泵抑制剂在疑似咽喉反流性疾病中的应用[J].中国耳鼻咽喉颅底外科杂志,2010,16(4):282-285

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  • 在线发布日期: 2010-08-31
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