Abstract: Objective To study the value of protonpump inhibitors (PPI) in the experimental treatment of suspected laryngopharyngeal reflux diseases (LPRD). Methods 65 patients with suspected LPRDs, according to the reflux symptom index (RSI) and reflux finding score (RFS), received shortterm Omeprazole (20 mg bid for two weeks) experimental treatment. The RSI and RFS were reevaluated two weeks after treatment. Results After treatment, RSI scores were descended in 38 cases (58.46%) and RFS scores descended in 29 cases (44.62%). Among the cases with steady RFS scores, 11 cases still got RSI scores descended. The differences of RSI and RFS scores were statistically significant before and after PPI experimental treatment. Conclusion Shortterm PPI experimental treatment, which can be administered to patients suffering from suspected LPRDs with good sensitivity and specificity, is worthy of extensive application in clinic.