Objective To investigate the application and curative effect of midfacial deglove in the surgical treatment of tumors of head and ncek. Methods Clinical data of 38 patients receiving surgical treatment of tumors of head and neck via midfacial deglove approach was analyzed respectively. Of them, the pathological diagnosis was benign in 14 cases and malignant in 24. According to UICC 2002 criteria, there were 5 patients in T1N0M0, 8 in T2N0M0, 7 in T3N0M0, 1 in T3N1M0 and 3 in T4N0M0. The midfacial deglove approach or modefied midfacial deglove approach was adopted to remove the tumor based on the state of patient’s lesion. Results The lesions were excised completely in 37 patients with a total removal rate of 97.4% (37/38). There were no postoperative complications such as stenosis of the nasal aperture or facial deformity. The functions of respiration, deglutition, phonation returned to normal in 36 patients. The 24 patients with manignant lesions had been followed up for 7 months to 6 years postoperatively. The 3year and 5year survival rates of the patients at T1, T2 stages were 85.7% and 80% respectively, and those of the patients at T3, T4 stages were 62.5% and 33.3% respectively. Conclusion With good curative effect, the midfacial deglove approach is an alternative for the surgical treatment of tumors of nasalparanasal cavities and those invloving anterior cranial fossa.