Abstract:Objective To investigate the clinical characteristics, diagnosis and treatment of laryngeal neuroendocrine carcinoma (LNEC). Methods The clinical manifestations, pathological features, diagnosis, treatment and prognosis of two patients with LNEC were analyzed retrospectively. Results The solitary tumors in the two cases were localized in the supraglottic region, with the diametars less than 2 cm. Partial laryngectomy was performed in both cases after preoperative patholgical confirmation. One case has been following up for 6 years without recurrence and the other is in followup. Conclusion LNEC is a rarely malignant tumor and the correct diagnosis relies on clinical characteristics, objective sign, histopathological feature and immunohistochemical examination. To be familiar with the clinical characteristics has important significance in the preoperative diagnosis, selection of operative mode, combination of postoperative radiotherapy and chemotherapy and improvement of postoperative survival rate of the patient.
