Abstract:Objective To study the relativity between the serum levels of matrix metalloproteinase (MMP-9), FFA and apneahypopnea index (AHI) , minimum oxygen saturation (SO2), blood lipids in OSAHS patients before and after continuous positwe airawy pressure (CPAP) treatment to present evidences for assessment of OSAHS and its relativity with cardiovascular and endocrine diseases. Methods Before CPAP treatment, PSG was monitored and the serum levels of MMP9, FFA and four lipids (TG, TCH, HDL, LDL) were determined in 50 patients with severe OSAHS. The abovementioned parameters were retested 6 months after treatment and compared with those before treatment. Results After treatment, the AHI got reduced (P<0.01) and SO2 increased (P<0.05). The serum levels of MMP9 and FFA after treatment (88.07±13.57 ug/ml, 0.71±0.22 mmol/l）were significantly lowered than those before treatment (123.09±39.03 ug/ml,0.87±0.23 mmol/l) (P<0.01) respectively. Serum levels of TG, TCH, LDL after treatment were also lower than those before treatment (P<0.01) while that of HDL got increased. Conclusion CPAP treatment can reduce serum levels of MMP9 and FFA in OSAHS patients, therefore effectively reduce OSAHSinduced inflammatory reaction and the incidence of cardiovascular disease.