Objective〓〖HQK〗〖WTBZ〗To evaluate the correlations among the expression of P53, COX2 , VEGF and microvessel density (MVD) in laryngeal carcinoma. 〖WTHZ〗Methods〓〖WTBZ〗Immunohistochemical staining was applied to detecting the expression of P53, COX2, VEGF proteins and MVD in 64 surgically resected specimens of laryngeal carcinoma. 〖WTHZ〗Results〓〖WTBZ〗Positive expression rates of P53, COX2, and VEGF proteins were 62.50%, 68.75%, and 71.88% respectively. The positive expression rates of P53, COX2 and VEGF proteins and the MVD values in specimens with cervical lymphatic metastasis were significantly higher than those without metastasis (P<0.05) . The mean MVD was 35.87±9.38. The expression of P53 and COX2 was positively correlated with that of VEGF (r=0.383, P＝0.002; r=0.305, P＝0.014). 〖WTHZ〗Conclusion〓〖WTBZ〗P53, COX2 and VEGF proteins may play an important roles in the angiogenesis of laryngeal carcinoma . Furthermore, the expression of VEGF and COX2 may be regulated by P53, involving in the process of cervical lymphatic metastasis of laryngeal carcinoma cells.〖HQ〗〖WT5”HZ〗