Objective To assess the shortterm effect of multilevel surgical treatment on severe obstructive sleep apneahyponea syndrome(OSAHS). Methods 32 patients with severe OSAHS confirmed by polysomnography (PSG) were enrolled. Their degree of hypnosia was recorded with Epworth sleep scale (ESS), airway narrowing degrees in retropalatal and retrolingual region were measured by Friedman tongue position method and Muller’s maneuver with fiberopticendoscopy. All patients received uvulopalatopharyngoplasty (UPPP) combined with tongue base radiofrequency (TBRF). Results Six months after operation, the Epworth score reduced from 14.2±3.1 to 3.3±2.3 (P<0.01), the average apneahypopnea index reduced from 57.1±5.3 to 23.4±4.5 (P<0.01) and the lowest pulse oxygen saturation (LSpO2) was improved from (71.3±4.6) % to (88.1±5.5) % (P<0.01). The total effective rate was 81.3% (26/32). Conclusion With good shortterm effect, UPPP combined with TBRF is an effective and safe multilevel surgical method for severe OSAHS, as TBRF can facilitate the improvement of therapeutic effect on UPPP for this disease.