Abstract:Objective To investigate the treatment option and efficacy of sudden deafness caused by enlargement of vestibular aqueduct. Methods 7 children with sudden deafness caused by enlargement of vestibular aqueduct from Jan 2011 to Dec 2011 in our department were enrolled in this study. The patients were divided into two groups according to the level of hearing loss before admission, and received different treatment. Ginkgo biloba extracts and glucocorticoids were applied to patients with mild or moderate hearing loss; gangliosides GMI and glucocorticoids to those with severe or profound hearing loss. The efficacy was observed. Results There was no significant difference between the effects of the two kinds of treatment when the level of hearing loss was mild or moderate. However, as for children with severe and profound hearing loss, the hearing was significantly improved when using Gangliosides GMI and glucocorticoids. Conclusion Gangliosides GMI and glucocorticoids have obvious significant efficacy especially in the treatment of severe and profound sudden deafness caused by enlargement of vestibular aqueduct.