EphA2与VEGF蛋白在喉鳞癌组织中的表达及相关性研究
DOI:
作者:
作者单位:

作者简介:

邱元正,Email:xyqyz@medmail.com.cn.

通讯作者:

基金项目:

国家自然科学基金(81172558),湖南省研究生学位论文创新基金资助(CX2011B059),中南大学自由探索计划青年教师助推基金(2012QNZT099),高等学校博士学科点专项科研基金课题(20090162110065


The expression and correlation of EphA2 and VEGF proteinin laryngeal squamous cell carcinoma
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
    摘要:

    目的 探讨沉默促红细胞生成素产生肝细胞受体(erythropoietinproducing hepatocellular receptor, EphA2)与促血管生成因子(VEGF)蛋白在喉鳞状细胞癌(喉鳞癌)组织中的表达及相关性。方法 采用免疫组织化学技术检测EphA2、VEGF蛋白在69例喉鳞癌组织及15例癌旁黏膜组织中的表达,分析二者表达水平与临床病理特征的关系。结果 EphA2和VEGF蛋白在喉鳞癌组织中的阳性率均高于癌旁黏膜组织(P均<0.05),EphA2蛋白表达尚与肿瘤原发部位相关(P<0.05),且EphA2和VEGF蛋白表达均与喉鳞癌患者的临床分期(P均<0.05)及转移(P均<0.05)密切相关,而二者表达与患者年龄、性别、组织学分级均无明显相关(P均>0.05)。喉鳞癌组织中EphA2及VEGF蛋白表达存在正相关性(P<0.05)。生存分析结果显示EphA2及VEGF蛋白表达水平与患者5年总生存率密切相关(P<0.05)。多因素Cox比例风险回归模型进一步显示,淋巴结有无转移及EphA2蛋白表达水平为喉鳞癌患者预后的独立影响因素。结论 EphA2与VEGF蛋白在喉鳞癌组织中表达均上调,提示二者可能存在相互作用,共同在喉鳞癌的发生、发展中起作用。

    Abstract:

    Objective To investigate the expression and biological significance of EphA2 and VEGF protein in tissue specimens of laryngeal squamous cell carcinoma (LSCC), and further study the correlation between the protein expression of EphA2 and VEGF. Methods The expression of EphA2 and VEGF protein was evaluated by immunohistochemical staining in 69 cases of LSCC specimens and 15 cases of adjcent epithelial tissue samples, and their correlation with clinicopathologic parameters was analyzed. Results The positive rates of EphA2 and VEGF in LSCC tissues were significantly higher than those in adjacent noncancerous mucosa (P<0.05), and the expression of these two marks was closely correlated with clinical stage (P<0.05) and metastasis (P<0.05) in patients with LSCC. Furthermore, the expression of EphA2 was also associated with tumor site (P<0.05). However, the expression of EphA2 and VEGF had no significant association with age, sex and histological differentiation (P>0.05). There was a positive correlation between the expression of EphA2 and VEGF (P<0.05). KaplanMeier survival analysis demonstrated that patients with high expression of EphA2 or VEGF had poorer overall survival compared with that in patients with relative low EphA2 or VEGF expression (P<0.05). Multivariate COX regression analysis revealed that both lymph node metastasis and EphA2 expression were independent prognostic factors for patients with LSCC. Conclusion Increased protein expression of EphA2 and VEGF in LSCC suggested that EphA2 and VEGF might play a critical role in the initiation and progression of LSCC.

    参考文献
    相似文献
    引证文献
引用本文

粟忠武 刘勇 余长云 李果 任舒灵 张欣 田勇泉 邱元正. EphA2与VEGF蛋白在喉鳞癌组织中的表达及相关性研究[J].中国耳鼻咽喉颅底外科杂志,2012,18(4):258-263

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2012-08-31
温馨提示

本刊唯一投稿网址:www.xyosbs.com
唯一办公邮箱:xyent@126.com
编辑部联系电话:0731-84327210,84327469
本刊从未委托任何单位、个人及其他网站代理征稿及办理其他业务联系,谨防上当受骗!

关闭