Objective〓〖HQK〗〖WTBZ〗To explore the predisposing factors, the preventive and therapeutical measures of pharyngeal fistula after total laryngectomy. 〖WTHZ〗Methods〓〖WTBZ〗The medical records of 114 patients who underwent total laryngectomy from 2000 and 2011 were assessed. Factors which might influence pharyngeal fistula formation such as patients’ age, preoperative radiotherapy, neck dissection, site of tumor and TNM stage were studied retrospectively. 〖WTHZ〗Results〓〖WTBZ〗Of all 114 patients, 12 got pharyngeal fistula (10.5%). The fistulas needed to be surgically closed in 7 cases, including direct suture of the pharyngeal mucosa in 6 and closure with pectoralis major myocutaneous flap in another one. Spontaneous closure with local wound care was achieved in 5. 〖WTHZ〗Conclusion〓〖WTBZ〗As for the pharyngeal fistula after total laryngectomy, there are many conflicting reports in literature concerning the predisposing factors. Our data shows that hemoglobin value, diabetes mellitus, tumor site, T and N grades and TNM stage of tumor are important predisposing factors. Most fistulas can be successfully managed with conservative treatment or direct surgical closure.〖HQ〗〖WT5”HZ〗