Objective To explore the effect of endoscopic surgery using electric coagulation and plasma radiofrequency for nasopharyngeal angiofibroma. Methods Clinical data of 5 patients suffering from nasopharyngeal angiofibroma and treated by endoscopic surgery using electric coagulation and plasma radiofrequency was analyzed retrospectively. The average intraoperative blood loss, tumor residual, duration of recovery, and tumor recurrence were evaluated. Results The tumor was completely removed in all 5 patients. The average blood loss was 426 ml, there was no postoperative complications and tumor residual in all patients. Patients were followedup for 3 months, the luminal epithelium of nasal endoscopic surgery; During the followup period of 1 year, 4 cases without recurrence, 1 was lost to followedup. Conclusion The endoscopic surgery with electric coagulation and plasma radiofrequency can be used for removing nasopharyngeal angiofibroma confining to nasal and nasopharyngeal cavities.