Objective To provide objective advice for clinical selection of tamping material via comparing the effect of two kinds of tamping materials in endoscopic sinus surgery. Methods 150 patients receiving nasal endoscopic surgery in our department from Nov. 2011 to March 2012 were randomly divided into two groups. Expansion sponge was adopted for nasal tamping in group A (n=77) and AcasinTM dressing in group B (n=73). The clinical effect of two kinds of tamping materials was evaluated via comparing the degree of nasal pain or headache using VAS, nasal hemorrhage after extraction of tamping material. Results The incidence rates of nasal pain or headache were 74.03% and 47.95% in group A and B respectively, and the difference was statistically significant (P<0.05). The incidence rates of nasal hemorrhage were 80.52% and 69.86% in group A and B, withno significant difference (P>0.05). Conclusion There is no obvious difference in hemostatic effect between expansion sponge and AcasinTM dressing. Although convenient in packing, nasal pain and headache are the disadvantages of expansion sponge. With advantages such as antibacterial activity, pain alleviation and targeted packing, nano silver antibacterial dressing is an ideal tamping material for nasal endoscopic surgery.