Objective:To explore the efficacy of transplantaion for repair nasal septal perforation with allograft nasal septal cartilage under nasal endoscope. Methods:From 2003 to 2011, 16 patients suffering from nasal septal perforation underwent transplantaion with allograft nasal septal cartilage under nasal endoscope by sandwich method. Postoperative nasal cleaning and management was applied periodically to all patients. Results:15 cases were primary healed with the surface of graft completely covered by nasal mucosa in 10 days to 8 weeks postoperatively. One patient got healed by second intention. Postoperative follow-up for 1 to 3 years showed no recurrence and any adverse reactions with a total effective rate of 100%. Conclusions:Endoscopic repair with allograft septal cartilage is an effective and practical method for nasal septal perforation.