Objective:To evaluate the efficiency of the pectoralis major myocutaneous flap (PMMF) for reconstruction of the defect after surgery of head and neck tumor. Methods:Clinical data of 36 cases receiving PMMF transfers for the reconstruction of postoperative defects in head and neck tumors from Jan 2007 to Dec 2010 was analyzed retrospectively. Results:Of all 36 cases, PMMF fully survived in 32(88.9%), partial distant necrosis of the flaps occurred in 4 patients (11.1%) and cured with conservative management.Conclusions:Pectoralis major myocutaneous flap is a functional and reliable choice for the reconstruction of postoperative defect in advanced head and neck tumor.