Objective:To evaluate the curative effect of ambroxol hydrochloride combined with glucocorticoids on secretory otitis media(SOM). Methods:Pubmed,Wanfang databases and CNKI were employed to retrieve the randomized controlled trial(RCT) with a relevance of the objective using the MeSH terms as “ambroxol hydrochloride” and “secretory otitis media” . Additional relevant reference cited in retrieval articles was also searched. The methodological quality of the trials and extracted valid data for Meta-analysis was evaluated. Results:Ten RCT studies fulfilled the inclusion criteria for Meta-analysis with a total sample size of 986 ears, including 521 of treatment group and 465 of control. Meta-analysis showed that the effect of treatment group was better than that of the control group. The pooled odds ratio for the overall effective rate was 3.17（P<0.05）.Conclusions:Ambroxol hydrochloride combined with glucocorticoid can improve the curative effect of SOM, which should be encouraged in clinical practice.