Objective:To briefly review the clinical characteristics including the causes，positions,and sizes of nasal septal perforations. Methods:Clinical data of 57 patients with nasal septal perforation was analyzed retrospectively. Nasal septum was divided into anterior portion and posterior portion by the border line between the quadrilateral cartilage and the perpendicular plate of the ethmoid. According to their maximal diameters, the perforations were classified into small(<1 cm), moderate(1~2 cm) and large(>2 cm) perforations. Results:Of all the 57 cases, perforations were induced by conventional nasal septoplasty in 33 cases including 30 of anterior portion and 3 of posterior. As for the size of perforation, the case number of small, moderate, and large type was 8, 15, and 10 respectively. Idiopathic factors (unknown factors) caused perforation of anterior portion in 7 cases with the case number of 1, 4 and 2 of small, moderate and large type. Trauma induced perforation in 5 cases including 3 of anterior portion and 2 of the posterior, the case number of moderate and large type was 3 and 2. Chemotherapy induced perforation in 5 cases, the perforation located at anterior portion in 2 cases and at posterior in 3 with the case number of small, moderate, and large type of 1, 3, and 1. Perforations were induced by infection in 5 cases, all at anterior portion, and the case number of small, moderate and large type was 2, 2 and 1 respectively. Tumor invasion induced perforation in 2 cases, both located at posterior portion and were moderate type .Conclusions:Surgical trauma during septoplasty is the major risk factor of nasal septal perforation featuring as moderate perforation at anterior portion of nasal septum.