Abstract:ObjectiveTo explore the feasibility of endoscopic resection of cavernous sinus (CS) tumors with epidural origin, and to introduce the selection of surgical approaches, protection of CS vital structure and controlling of CS bleeding.MethodsBased on the originating site and extension of the tumor, five endoscopic approaches were selected for the resection of 39 CS tumors with epidural origin, including endoscopic transseptal transsphenoidal approach, extended endoscopic transseptal transsphenoidal approach, extended transnasal transmaxillary approach, endoscopic transnasal transpterygoid approach, and extended extranasal maxillary sinus approach. Of all these 39 CS tumors, 17 were pituitary adenoma, 5 nasopharyngeal fibroangioma, 6 schwannoma, 6 chordoma, 2 adenoid cystic carcinoma, 2 fibrosarcoma, and one fibrosarcoma.ResultsAs for the surgery, total and subtotal tumor resection got achieved in 33 (84.6%) and 6 (15.4%) respectively. No disabling or fatal complications occurred.ConclusionCS tumors with epidural origin can be effectively resected via endoscopic approaches. Appropriate selection of the surgical approaches, effective protection of vital CS anatomical structure, efficient reduction of CS bleeding are essential for success.