Abstract:ObjectiveTo study the expression of peIF4E and pMnk1 in the head and neck squamous cell carcinoma (HNSCC) and its clinical significance.MethodsExpression of peIF4E and pMnk1 was detected in 60 samples of HNSCC and 35 of pericancer tissues by tissue microarray immunohistochemical SP method.ResultsThe positive expression rates of peIF4E and pMnk1 in HNSCC were significantly higher than those of pericancer tissues (both P<0.01). The expression of peIF4E was correlated with pathological grading and clinical stages of HNSCC (P<0.05). The expression rate of pMnk1 in HNSCC with lymphatic metastasis was significantly higher than that without metastasis (P<0.05). In addition, the expression of peIF4E was positively correlated with that of pMnk1 in HNSCC (r=0.361, P=0.005).ConclusionsThe abnormal expression of peIF4E and pMnk1 is related to the development, invasion and metastasis of HNSCC. Coexpression of peIF4E and pMnk1 has a possible synergistic action that may promote the carcinogenic process of HNSCC.