ObjectiveTo explore the therapeutic effect of different surgical approaches for the treatment of fungal maxillary sinusitis.MethodsClinical data of 94 patients with fungal maxillary sinusitis was analyzed retrospectively. All patients were treated surgically. Three kinds of surgical approaches were adopted, including CaldwellLuc surgery (n=31), endoscopic maxillary ostium surgery (n=33) and endoscopic maxillary ostium surgery combined with inferior meatus fenestration (n=30). The therapeutic effect was evaluated.ResultsAll patients were followed up for 12 months postoperatively. The patients′ curative ratio treated with CaldwellLuc surgery is 74.2%(23/31), Five had facial numbness, none got epiphora and nasal adhesion. The patients′ curative ratio treated with endoscopic maxillary ostium surgery is 81.8%(27/33), 7 had nasal adhesion, none got epiphora and facial numbness. The patients′ curative ratio treated with endoscopic maxillary ostium surgery combined with inferior meatus fenestration is 100%, none recurred, and 5 had nasal adhesion. ConclusionEndoscopic maxillary ostium surgery combined with inferior meatus fenestration is a minimally invasive, safe and effective approach for the surgical treatment of fungal maxillary sinusitis