Abstract:ObjectiveTo explore the curative effect on vocal process granuloma treated with Zinc Sulfate.Methods15 patients with vocal progress granulomas between 2007 and 2012 were treated, 100 ml (200 mg) Zinc Sulfate liquid was taken orally after a meal, three times a day. Since then, all patients were observed and regularly monitored with telescopic examinations every month, then rechecked every 3 months for 1 year. An endoscopic grading system for vocal process granuloma were adopted to assess the curative effect by contrasting the initial images with those after the medical intervention.ResultsAfter therapy mentioned above, in 12 patients the vocal process granulomas disappeared in 1 month，2 in 2 months and 1 in 3 months separatively; hoarseness, sore throat, lumping sensation in the throat, and cough were improved apparently. No recurrence was seen in 15 patients after followedup for 1 year. No complications happened.ConclusionZinc Sulfate treatment is a safe and effective method on resolving vocal process granulomas,especially in those cases of postoperative recurrence. so it is good either as an initial or a compensatory treatment.