ObjectiveTo observe the therapeutic effect of nasal endoscopic Eustachian tube insufflation and Sinupret oxygen atomizing inhalation for the treatment of secretory otitis media(SOM).Methods76 patients were randomly divided into control group and treatment group. The control group was given routine drug treatment, endoscopic examination of Eustachian orifice, vacuum aspiration and insufflation of Eustachian tube with simultaneous Sinupret oxygen atomizing inhalation were applied to the treatment group. The therapeutic effect was evaluated.ResultsWith the single course of treatment, the control group’s total efficiency is 72.1%, the total effective rate of treatment group is 93.2%, the two groups have significant differences in the total efficiency(P<0.01). The clinical curative effect with the double treat, the control group’s total efficiency is 86.8%, the treatment group’s total efficiency is 95.4%, the two groups haven’t significant differences in the total efficiency(P>0.05).ConclusionWith advantages of function recovery of Eustachian tube, early symptom relief and hearing improvement, endoscopic Eustachian tube insufflation combined with Sinupret oxygen atomizing inhalation is effective for the treatment of SOM.