ObjectiveTo investigate clinical effect and influence factors of endoscopic sinusitis surgery (ESS) for chronic rhinosinusitis (CRS).MethodsClinical data of 270 patients with CRS treated by ESS from Jan. 2010 to Dec. 2011 were analyzed retrospectively. The clinical effect was evaluated 6 months after operation according to the evaluation standard for ESS and logistic regression analysis was performed to analyze the risk factors.ResultsThe postoperative followup results showed a total disease control rate of 87.78%(237/270). The disease control rate of CRS patients without nasal polyps was 92.47%(135/146), which was significantly higher than that of the CRS patients with nasal polyps (82.26%,102/124) (χ2=6.512,P=0.011), The curative effect of CRS patients without nasal polyps was significantly better than that of ones with nasal polyps (χ2=7.539,P=0.023). Logistic regression analysis showed that clinical classification, allergic rhinitis, visual analogue scale score, LundMackay score, LundKennedy score, recurrence and postoperative followup compliance were the major risk factors for ESS.ConclusionsLogistic regression analysis showed the clinical effect and influence factors of endoscopic sinusitis surgery (ESS) for chronic rhinosinusitis (CRS) was accompanied by nasal polyps, and also related to other factors.