ObjectiveTo determine the clinical value of plasma 13βD glucan assay for diagnosis of fungal rhinosinusitis.MethodsClinical data of 87 patients underwent surgical treatment for nasal diseases in our department was analyzed retrospectively. According to the postoperative pathological results, all the patients were divided into two groups, experimental group (fungal rhinosinusitis group,n=41) and control group(n=46). The plasma levels of 13βD glucan in all the patients of both groups were detected and compared. The specificity and sensitivity of plasma 13βD glucan assay for the diagnosis of fungal rhinosinusitis were calculated.ResultsThe average preoperative plasma level of 13βD glucan in the experimental group (18.3±3.2 pg/ml) was higher than that of the control group (2.5±3.4 pg/ml) with statistically significant difference (t=22.24，P<0.05). In the experimental group, the postoperative plasma level of 13βD glucan (2.8±2.6 pg/ml) was significantly lower than the preoperative level （18.3±3.2 pg/ml）with statistically significant difference (t=24.07，P<0.05). For the diagnosis of fungal rhinosinusitis via detection of plasma 13βD glucan, the sensitivity was 95.1% and specificity was 84.8%.ConclusionsPlasma 13βD glucan assay for diagnosis of fungal rhinosinusitis is reliable and convenient with high sensitivity. Meanwhile, this assay can be used for monitoring the surgical efficacy. Therefore, the detection of plasma 13βD glucan is worthy of being widely applied to clinical medicine.