ObjectiveTo provide basis and guidance for early clinical diagnosis and treatment by summarizing the clinical features of leprosy.MethodsOne case of nasal leprosy confirmed by pathology and AFB stain was presented. Combined with literatures review, the clinical features, laboratory examination, diagnosis and treatment of this disease were analyzed.ResultsNasal leprosy was an infectious disease caused by nasal mucosa infection with Mycobacterium leprae. Its main lesions included nasal mucosa hypertrophy, nasal leproma, nasal bone destruction and malformation, body skin lesion and peripheral neuritis. The diagnosis was relied on AFB stain and pathology. Clinical cure of this disease could be achieved by nasal surgery combined with chemotherapy.ConclusionsNasal leprosy is a bacteriuminfected chronic infectious and granulomatous disease with a variety of symptoms and signs involving nasal cavity, body skin, peripheral nerve, even malformation. Misdiagnosis and missed diagnosis of this disease are easy to occur due to its atypical early symptoms and signs. Early diagnosis, nasal surgery combined with chemotherapy are essential for clinical treatment.