Abstract:ObjectiveTo explore the expressions of serine/threonine kinase AKT/PKB and hexokinase2 (HK2) in laryngeal squamous cell carcinoma, and study the relationship between their expressions and all pathological factors of this tumor.MethodsImmunohistochemical Streptavidianperosidase (SP) method was used to examine the expressions of AKT and HK2 in 30 specimens of laryngeal squamous cell carcinoma and 30 of paracarcinoma tissue.ResultsThe expressions of AKT and HK2 in carcinoma specimens were higher than those in paracarcinoma tissues, and their expressions were closely related with differentiation and lymphatic metastasis of the tumor (all P＜0.05). The expressions of AKT and HK2 were not related to patients’ age, primary position and clinical stage of the tumor (all P＞0.05). Spearman’s rank correlation analysis showed that the expression of AKT was positively correlated with that of HK2 (r=0.424，P=0.019).ConclusionIn laryngeal squamous cell carcinoma, the expressions of AKT and HK2 are significantly related with invasion and metastasis, which prompts poor prognosis of the tumor.