Abstract:ObjectiveTo study the expressions of indoleamine 2,3dioxygenase (IDO) and bridging integrator 1(BIN1) in laryngeal squamous cell carcinoma, and to analyze their clinicopathological significances.MethodsThe expressions of IDO and BIN1 in 50 specimens of laryngeal carcinoma and 23 of normal laryngeal mucous tissues were detected by immunohistochemical staining, and correlation between the two expressions and their relations with clinical characteristics of the patients were analyzed.ResultsThe positive expression rates of IDO were 60％ and 17.39％ in specimens of laryngeal carcinoma and normal laryngeal mucous tissue respectively, and the difference was statistically significant (P<0.01). The positive expression rates of BIN1 in specimens of laryngeal carcinoma and normal laryngeal mucous tissue were 50％ and 95.65%, and the difference was also statistically significant (P<0.01). Comparing primary tumors with metastatic ones，the expression level of IDO was upregulated, while that of BIN1 was downregulated with statistically significant differences (both P<0.05). The expression of IDO protein was associated with lymph node metastasis and clinical stage of the tumor，while the expression of BIN1 protein was associated with degree of differentiation, lymph node metastasis and clinical stage of the tumor.ConclusionsIn laryngeal squamous cell carcinoma specimens and metastatic cervical lymph nodes，the expression level of IDO is upregulated significantly and that of BIN1 is downregulated，which is closely associated with clinical features of the tumor. IDO and BIN1 might be important factors affecting occurrence and progression of laryngeal squamous cell carcinoma.