ObjectiveTo explore changes of testosterone level in adult male patients with obstructive sleep apneahypopnea syndrome (OSAHS).MethodsThe data of 183 adult male patients with OSAHS (OSAHS group) and 60 normal men (control group) were analyzed retrospectively. All the subjects in both groups were monitored by polysomnography (PSG) and assigned to 25-40 years old subgroup and 40-55 years old subgroup. Of the 183 cases in OSAHS group, 52 cases were mild, 58 were moderate, and 73 were severe according to apnea hypopnea index (AHI). Their serum levels of testosterone were measured after PSG monitoring. The effect of OSAHS on testosterone level in adult male patients with OSAHS was analyzed via comparing the differences of testosterone level between the same age subgroups of both groups.ResultsThe serum levels of testosterone in the 2 age subgroups of OSAHS group were lower than those of the control group, and the differences were statistically significant (both P<0.05). The differences of testosterone level among the mild, moderate and severe OSAHS patients of the same age subgroups were also statistically significant (all P<0.05).ConclusionThe serum level of testosterone in adult male patients with OSAHS is lower than that of normal men, which is potentially useful in clinic.