ObjectiveTo explore the effect of combination of rabeprazole, domperidone and Xiqingguo granule for the treatment of laryngopharyngeal reflux (LPR) complicated with laryngopharyngitis.MethodsThe clinical data of 75 patients with LPR complicated with pharyngitis treated in our hospital from March 2014 to May 2015 were analyzed retrospectively. According to the treatment methods, the patients were divided into western medicine treatment group (n=40) and combined treatment group (n=35). To the patients of the western medicine treatment group, rabeprazole and domperidone were administrated orally. For those of the combined treatment group, Xiqingguo granule (a traditional Chinese medicine preparation) was administrated in addition with rabeprazole and domperidone. The course of treatment was 3 months for both groups. Their therapeutic effects were evaluated and the incidences of adverse reactions were analyzed. The differences of reduction in reflux symptom index (RSI), reflux finding score (RFS) and symptom alleviating time between the two groups were compared.ResultsThe effective rate of the combined treatment group was 97.14%, which was significantly higher than that of the western medicine treatment group (80.00%) (χ2=5.195, P=0.023). The difference of RSI before treatment between the two groups was statistically insignificant (P>0.05). After treatment, the scores of hoarseness or vocal problems, clearing throat and excess throat mucus of the combination treatment group were lower than those of the western medicine treatment group (all P<0.05). The difference of RFS before treatment between the two groups was also statistically insignificant (P>0.05). After treatment, the scores of subglottic edema, ventricular obliteration, erythema and hyperemia of the combination treatment group were lower than those of the western medicine treatment group (all P<0.05). The symptom alleviating time for globus sensation, chronic cough, clearing throat and hoarseness of the combination treatment group was significantly shorter than that of the western medicine treatment group respectively (all P<0.001). The difference of the incidence rate of adverse reactions including impaired kidney and liver function, abdominal distension and tiredness between the two groups were statistically insignificant (χ2=0.008, P=0.930).ConclusionWith advantages of dramatically improving clinical symptoms and signs, and reducing the incidence of adverse reactions, the combination of traditional Chinese medicine and western medicine shows good curative effect for LPR complicated with laryngopharyngitis, so it is worthy of clinical application.