ObjectiveTo explore the quality of life (QOL) in patients suffering from chronic rhinosinusitis with nasal polyps after primary endoscopic sinus surgery (PESS) and revision endoscopic sinus surgery (RESS).MethodsA prospective trial was conducted to survey the QOL of 30 patients treated with RESS and 40 with PESS. All the patients were evaluated by visual analog scale (VAS), item20 sinonasal outcome test (SNOT20), LundKennedy staging system before operation (as the baseline) and 12 months after operation.ResultsThe total scores of SNOT20 and 5 most important items in SNOT20 and LundKennedy scores of the patients in both groups at 12 months after surgery were less than those of their baselines respectively(all P<0.05). At that time, the difference of SNOT20 scores between the PESS group and the RESS group was statistically insignificant (P>0.05). The 5 items most frequently reported as important before operation were “Need to blow nose”, “Postnasal discharge”, “Thick nasal discharge”, “Dizziness” and “Lack of a good night’s sleep” in both groups. At 12 months after surgery, “Frustrated/restless/irritable” became one of the 5 most important items in the PESS group while “sad” in the RESS group.ConclusionsAs a therapeutic means that can be adopted repeatedly, relief clinical symptoms significantly and improve QOL, endoscopic sinus surgery is effective for both primary and recurrent chronic rhinosinusitis. The problems of “sad” and “Frustrated/restless/irritable” should be sufficiently emphasized in clinical treatment.