Abstract:ObjectiveTo determine whether the vocal vowel analysis and dysphonia severity index (DSI) can be applied to the differential diagnosis of common laryngeal diseases.MethodsStatistical analysis was performed on sustained vowel test and range test of vocal acoustic analysis in 811 patients with laryngeal diseases. The patients were divided into 8 groups according to the diagnosis. One-Way ANOVA test was used to analyze the data, and the Dunnett T3 test was selected to analyze the comparisons between the two groups, the test standard alpha=0.05.ResultsThe results of One-Way ANOVA test showed significant statistical differences in F0min, Jitter, Shimmer, and SPLmax among groups in male patients (all P<0.05), and in F0, Jitter, F0max, F0min, SPLmax, SPLmin among groups in female patients (all P<0.05). Dunnett T3 test revealed no statistically differences in the parameters of the vocal acoustic analysis between any two laryngeal disease groups except those of Jitter, F0max between laryngeal carcinoma group and Reinke’s edema group, vocal polyp group and Reinke’s edema group, F0max between vocal leukoplakia group and Reinke’s edema group, SPLmax between vocal polyp group and laryngeal carcinoma group in male patients, and those of SPLmax between vocal cyst group and vocal cord paralysis group, vocal nodules group and vocal cord paralysis group, DSI between vocal polyp group and vocal nodules group in female patients.ConclusionVocal acoustic analysis can be used to assess the level of dysphonia, but the current parameters can’t be applied to effectively differentiate laryngeal diseases.