ObjectiveTo explore the diagnosis and treatment principle of giant cell tumor of skull base.MethodsThe experience in the treatment of pathologically confirmed giant cell tumor of skull base in 14 cases admitted in our hospital from Aug 2007 to April 2017 was summarized.ResultsOf all the 14 cases, tumor involved temporal bone in 8, sphenoid bone in 5 and ethmoid bone in one. The surgical approaches included endoscopic endonasal approach (EEA), infratemporal fossa approach (ITFA), combined EEA and ITFA approach and middle cranial fossa approach (MCFA). Total tumor removal was achieved in 11 patients, while subtotal removal was achieved in 3. There were no severe surgical complications. All the patients had been followed up for 8 months to 10 years. Two in the three patients who could not get total tumor removal received postoperative radiotherapy. None of the 14 cases got tumor recurrence or progression.ConclusionsGiant cell tumor of skull base is rare and difficult to be diagnosed. Certain characteristics can be found in clinic and radiology. Surgery is the preferred treatment method for this tumor. The choice of surgical approach should be individualized.