ObjectiveTo explore the feasibility and curative effect of resection of deeplobe parotid pleomorphic adenoma via a pure endoscopic transoral approach.MethodsSix patients with pleomorphic adenoma of deeplobe parotid gland (4 males and 2 females, ranging in age from 18 to 56 years old with an average of 36) received direct surgical resection of tumor via endoscopic transoral approach. As for the symptoms and signs, lateral pharyngeal wall bulging was detected in 2 patients in health examinations, one patient complained of headache, and the other 3 complained of throat indisposition.ResultsComplete removal of the tumor was achieved in all the 6 cases, and no complications such as facial paralysis, hoarseness and dysphagia occurred. Postoperative swelling and pain in the parotid area occurred in one patient and got improved through antiinfective therapy combined with pressure dressing. All patients had been followed up for 12 months to 40 months with an average of 24. Tumor recurrence occurred in one patient due to malignant transformation 2 years after operation.ConclusionPleomorphic adenoma of deeplobe parotid gland can be resected completely via endoscopic transoral approach which is safe, minimally invasive, and capable of reserving facial nerve function. Nonetheless, open surgical approach is recommended for the resection of malignant parotid tumors.