ObjectiveTo analyze the clinical manifestations, treatment method, and prognosis of RosaiDorfman disease (RDD) in head and neck.MethodsClinical data of 10 cases suffering from RDD in head and neck region between 1986 and 2017 were analyzed retrospectively. The data analyzed included clinical and pathological features, treatment and prognosis.ResultsOf the 10 patients, 6 were male and 4 were female. Their age ranged from 22 to 27 years old with a median age of 36.5. The lesions mostly involved nose (9 cases) and throat (6 cases). Eight cases had 2 or more regions involved. The clinical features were related to the locations and extent of the lesions. Glucocorticoid treatment combined with surgical resection was carried out for these patients. The median followup duration was 90 months (3 to 384 months). One case was lost to followup, one case was cured, and the remaining 8 cases were alive with disease.ConclusionsAll the patients diagnosed as RDD need a thorough examination of otolaryngology. The clinical characteristics and imaging features of RDD are nonspecific. The diagnosis for RDD relies on histopathologic examination of biopsy. The regimen of glucocorticoid therapy combined with surgical resection can stabilize the patients' condition with favourable prognosis. Regular followup is important in the management of this disease.