ObjectiveTo explore the effect of absorbable medical film for the prevention of postoperative middle ear adhesion.Methods36 guinea pigs with normal hearing threshold and without ear diseases were included in this study. The animals were randomly and equally divided into three groups. In order to induce otitis media, all guinea pigs underwent permanent clogging of the eustachian tube. Meanwhile, an absorbable medical film was implanted on the promontory surface of animals in the experiment group I and a silicon member in the experiment group II. The animals of the control group received only clogging without implantation. At the 15th and 90th day after the process, 6 animals in each group were sacrificed to observe the preventive effect of implants on middle ear adhesion.ResultsThe threshold change in the experiment group I was smaller than those in the experiment group II and the control group respectively, their differences were statistically significant (both P<0.05). Histopathological study of the tympanic bullae demonstrated less granulomatous and fibrous tissue, localized encapsulation with development of lacunae in the experiment group I, which indicated that the absorbable medical film had good preventive effect for postoperative middle ear adhesion.ConclusionWith good biocompatibility, absorbable medical film is an excellent biological material to prevent middle ear adhesion.