ObjectiveTo evaluate the efficacy, safety and feasibility of endoscopeassisted resection of submandibular gland through intraoral approach.MethodsUnder general anesthesia with pernasal intubation, a curved incision was made along the tongue mandibular groove. The gland and associated nerves, vessels and ducts were then resected with assistance of endoscope. ResultsSubmandibular gland was safely resected in all 5 patients. Temporary lingual sensory paresis occurred in one patient, and got recovered within 2 weeks. No damage to marginal mandibular branch of the facial nerve and hypoglossus was found. Other postoperative complications occurred in none. No neck scar was found with good cosmetic results.ConclusionEndoscopeassisted intraoral approach is safe and feasible for the resection of submandibular gland, which is worthy of clinical application.