ObjectiveTo investigate the efficacy, feasibility and safety of appropriate dose of fentanyl in anesthesia without controlled hypotension for endoscopic sinus surgery.MethodsFortyfive patients (ASA gradeⅠor Ⅱ degree, between the ages of 18 and 45, after standardized treatment to control inflammation) undergoing endoscopic sinus surgery were randomly assigned into three groups. During induction of anesthesia, intravenous injection of fentanyl 3 μg/kg was given to all patients in the three groups. Before the start of the operation, fentanyl of 1.5 μg/kg, 2.5 μg/kg and 3.5 μg/kg was supplemented to the group I, II and III respectively. Continuous hemodynamics monitoring was performed. At timepoints before induction(T1), at the beginning of operation(T2), at 15 min (T3), 30 min (T4), and nasal packing (T5), the hemodynamic parameters including systolic pressure (SP), diastolic pressure (DP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV) and cardiac output (CO) were recorded. Score of surgical field quality (SSFQ) was adopted to evaluate surgical field quality by the same surgeon. The extubation time and postoperative complications were also recorded.ResultsAt the timepoints T3 and T4, the MAP, HR and CO of both group II and III were lower than those of the group I, their differences were all statistically significant (all P<0.05). Meanwhile, the differences between group II and III were all statistically insignificant (all P>0.05). The SSFQ scores of group II and III were higher than that of group I (both P<0.05) while the difference between group II and III was insignificant (P>0.05). As for the extubation time, the difference between group I and group II was insignificant (P>0.05) and that of group III was significantly prolonged (P<0.05). No obvious adverse reactions occurred in group II.ConclusionAnesthesia without controlled hypotension, given fentanyl 3 μg/kg in the induction of anesthesia and supplemented fentanyl 2.5 μg/kg prior to the start of surgery, can ensure the successful completion of endoscopic surgery. This anesthesia method is effective, safe and feasible.