In recent years, the "superantigen" hypothesis has been proposed in the etiology of chronic rhinosinusitis (CRS). Enterotoxins (SEs) produced by staphylococcus aureus are typical superantigens(Sag). Traces of SEs are sufficient to stimulate massive proliferation of multiple nonspecific T cells, thereby inducing release of various cytokines which play important roles in the occurrence and development of diseases. This paper reviews the structure and mechanism of SEs as well as recent study on its correlation with CRS.