ObjectiveTo explore the clinical features and surgical treatment of ossifying fibroma of paranasal sinuses.MethodsClinical data of 18 patients suffering from ossifying fibroma of paranasal sinus surgically treated in our department from Jan 2011 to June 2017 were analyzed retrospectively. Of them, 11 were male and 7 were female, with an age range of 8 to 37 years (average age 15 years). Tumor resection was performed via nasal endoscopic approach in 15 cases, and nasal endoscopic approach combined with coronal incision in 3.ResultsIn this study, complete tumor resection was achieved in 14 cases and partial resection in 4. Clinical symptoms including facial swelling, exophthalmos, dislocation of eyeball, nasal obstruction, epistaxis and headache were improved in varying degrees. Of two patients with hyposmia, olfaction returned to normal in one. Of 5 cases with impaired vision, visual acuity got improved in 2 and kept unchanged in 3. No serious complications such as blindness, cerebrospinal fluid rhinorrhea, intracranial infection and hemorrhage occurred. All patients had been followed up for 6 months to 8 years. The results showed no recurrence in 12 patients, recurrence in 2 and survival with residual tumor in 4.ConclusionWith advantages of protection of sinusal structures and function, as well as facial esthetic, endoscopic sinus surgery combined with scalp coronal approach if necessary maybe eligible for most patients with ossifying fibroma of paranasal sinuses. However, it requires surgeons with wealth of knowledge about endoscopic anatomy and high surgical skills.