ObjectiveTo assess the relationship between serum lipopolysaccharidebinding protein (LBP) and carotid intimalmedia thickness (CIMT) in patients with obstructive sleep apneahypopnea syndrome (OSAHS).Methods117 suspected OSAHS patients visited our hospital from May 2015 to Dec 2017 were selected as the study subjects. All patients received polysomnography and CIMT assessment by Bmode ultrasound.ResultsLBP concentrations and average CIMT increased from patients without OSAHS to those with mildmoderate and severe OSAHS ［from （32.1±10.4） to （32.3±10.8） to （38.1±10.5）μg/ml, P=0.017; from （0.52±0.08） to （0.58±0.07） to （0.62±0.13）mm，P=0.006, respectively］. Oxygen desaturation index (ODI) was a predictor of serum LBP level independent of age, waistto hip ratio (WHR), smoking, hypertension, HDL cholesterol, triglycerides and fasting glucose （P=0.002, R2=0.154）. Furthermore, serum LBP predicted CIMT independently of known risk factors of atherosclerosis including obesity (P<0.001 R2=0.323).ConclusionThere is a correlation between LBP and CIMT in a linear manner in patients with OSAHS