ObjectiveTo investigate the application value and effect on neurological function of propofol combined with lidocaine in the anesthetic pretreatment in patients with craniocerebral tumor surgery.Methods90 patients with craniocerebral tumors undergoing surgical treatment were enrolled in this prospective study. All the patients were randomly divided into control group and observation group. The patients in both groups received anesthetic pretreatment with propofol, while lidocaine was added to those of the observation group. Before and after operation, evaluations including neurological function deficits assessment (NFA), FuglMeyer motor function assessment (FMA), Barthel Index (BI) and Hamilton depression rating scales (HAMD) were performed in all patients of both groups. Meanwhile, their pre and postoperative serum levels of superoxide dismutase (SOD) and neuron specific enolase (NSE), IL1, TNFα were detected. All the results were compared.Results①The preoperative score differences of NFA, FMA, BI and HAMD between the observation group and the control group were statistically insignificant (all P>0.05). The differences between the preoperative scores of NFA, FMA and the postoperative ones in both groups were all statistically significant (all P<0.05), with increased NFA and decreased FMA. The differences of postoperative scores of NFA, FMA between the observation group and the control group were statistically significant(both P<0.05), with lower NFA and higher FMA in the observation group. The differences between the preoperative scores of BI, HAMD and the postoperative ones in both groups were all statistically significant (all P<0.05), with increased HAMD and decreased BI. The differences of postoperative scores of BI, HAMD between the observation group and the control group were statistically significant (both P<0.05), with lower HAMD and higher BI in the observation group； ②The preoperative serum level differences of SOD, NSE, IL1 and TNFα between the observation group and the control group were statistically insignificant (all P>0.05). The differences between the preoperative serum level of SOD, NSE, IL1 as well as TNFα and the postoperative ones in both groups were all statistically significant (all P<0.05), with increased SOD, NSE and decreased IL1 and TNFα. The differences of postoperative serum level of SOD, NSE, IL1 as well as TNFα between the observation group and the control group were statistically significant(all P<0.05), with higher serum levels of SOD, NSE, IL1 and TNFα in the observation group. ConclusionThe anesthetic pretreatment by propofol combined with lidocaine can effectively alleviate the inflammation and reduce the neurological damage in patients undergoing craniocerebral tumor surgery, which is beneficial to postoperative recuperation of motor function and activities of daily living, and prevention of depression.