ObjectiveTo investigate the clinical efficacy and feasibility of parapharyngeal space tumor resection via endoscopic transoral approach.MethodsClinical data of 15 patients with parapharyngeal space tumors undergoing resection via endoscopic transoral approach between July 2013 and Aug. 2017 in our department were analyzed retrospectively.ResultsMost of the patients complained of pharyngeal foreign body sensation, obstruction in swallowing and vocal vagueness. However, parapharyngeal space occupying lesion was revealed by imaging examination in some patients without any symptoms. Endoscopic transoral approach was successfully applied in tumor resection in all the cases. Neither postoperative facial and skin incision scars nor complications such as regional infection, hemorrhage, and hoarseness occurred. Postoperative followup for 6 months to 4 years showed no recurrence.ConclusionsEndoscopic transoral approach is effective for surgical resection of parapharyngeal space tumors. With assistance of endoscopic system, the disadvantages of conventional approaches including small exposure field and operation space as well as blindness of operation can be effectively solved. With advantages of less trauma, rapid recovery, high cure rate and cosmetic appearance, endoscopic transoral approach is worthy of clinical promotion.