LncRNA在喉癌发病机制中的作用及其研究进展
作者简介:

马俭,Email:mj0607@sina.com

基金项目:

南京市医学科技发展项目 (YKK12093)


Research advances of long noncoding RNAs in laryngeal carcinoma
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    摘要:

    长链非编码RNA(long noncoding RNA,LncRNA)是一类长度超过200 nt,且不能编码蛋白质的RNA。LncRNA可通过表观转录调控以及转录后调控等多种调控方式参与肿瘤的发生、发展过程。喉癌是常见的头颈部恶性肿瘤之一,近来研究发现多种LncRNA在喉癌中异常表达,可作为喉癌早期诊断及评估预后的标志物。本文对国内外相关文献中数个与喉癌关系紧密的LncRNA进行综述,期望为喉癌的基因靶向治疗提供依据。

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    Abstract:

    Long noncoding RNAs (LncRNAs) are a class of RNAs that are more than 200 nt in length and cannot encode proteins. LncRNAs can be involved in the occurrence and development of tumors through various regulatory modes such as epigenetic transcriptional regulation and posttranscriptional regulation. Laryngeal carcinoma is one of the most common malignant tumors in head and neck. Recent studies have found abnormal expressions of various lncRNAs in laryngeal carcinoma, which can be used as markers for the early diagnosis and prognosis evaluation of this tumor. In this paper, domestic and overseas literatures about several LncRNAs closely related to laryngeal carcinoma were reviewed so as to provide a basis for genetargeted therapy of laryngeal carcinoma.

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引用本文

邓陈虎,马俭,张丙文,邢奋丽,高志伟. LncRNA在喉癌发病机制中的作用及其研究进展[J].中国耳鼻咽喉颅底外科杂志,2019,25(1):99-103

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  • 在线发布日期: 2019-02-26
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