ObjectiveTo explore the application of computerassisted navigation and feasibility of generalizing this technique in removal of traumatic foreign body in deep head and face region. MethodsClinical data of 6 patients suffering from traumatic foreign body in deep head and face region treated in our department from Sept. 2015 to May 2018 were analyzed retrospectively. Of them, 5 were male and one was female. As for the location of foreign body, 2 were located in nasal cavity and sinus，1 in head and face due to gunshot，1 in retropharyngeal space and 2 in tongue root. All patients received first treatment such as local debridement and hemostasis, as well as prophylactic antibiotics. Computerized tomography (CT) scans were performed and data were saved in digital imaging and communications in medicine (DICOM) format. The foreign body was located, measured and displayed by preoperative individualized design. Removal of foreign body was performed under the guidance of navigation system in all patients.ResultsForeign body was removed completely and safely in all patients without injury of important blood vessels and nerves. Postoperative 3month followup and CT reexamination revealed neither surgical complications nor residual foreign body in all patients.ConclusionFor patients with foreign body in nasal and facial trauma, preoperative individualized surgical plan and intraoperative realtime navigation are conducive to identify the foreign body rapidly and accurately and remove the foreign body completely and safely. Intraoperative realtime navigation can help the surgeon to avoid the damage of important blood vessels and nerves so that to reduce shortterm and longterm surgical complications.