ObjectiveTo investigate the repair method of local defect after tumor resection with laryngeal function preservation in hypopharyngeal carcinoma.MethodsClinical data of 33 patients receiving defect repair after tumor resection with laryngeal function preservation in hypopharyngeal carcinoma in our department from March 2013 to Dec 2018 were analyzed retrospectively.Of them, the defects were closed by direct mucosal suture in 14 cases, repaired with sternohyoid fascial flap in 2, heterologous bovine acellular dermal matrix membrane in 4, pectoralis major myocutaneous flap in 2, supraclavicular island flap in 4, free anterolateral thigh flaps in 4 and esophageal uplift and gastric migration in 3. All the patients were followed up to evaluate their wound healing.ResultsAll the 33 patients had good laryngeal function, and 3 had mild aspiration in the early stage and got normal feeding after twoweek exercise. Swallowing function got recovered in all cases with 2 of esophageal entrance stenosis improved with local expansion, and 2 of pharyngeal fistula healed by onemonth local dressing. All the patients had been followed up for more than one year with a oneyear survival rate of 78.79% (26/33), and the survivors are under follow up.ConclusionsIn the postoperative defect repair of hypopharyngeal carcinoma with laryngeal function preservation, prevention of aspiration and avoidance of pharyngosterosis and esophagostenosis are the main targets. Individualized repair method based on the the patient condition is capable of restoring the structure and function of hypopharynx while avoiding unnecessary secondary damage.